39. Tate, R.B., Manfreda, J., Cuddy T.E.: The effect of age on risk factors for ischemic heart disease: The Manitoba Follow-up Study, 1948-1993. Ann Epidemiol 8: 415-421, 1998. (with editorial comment)

Purpose: The purpose of this paper is to determine the age-specific relationships between risk factors at age 40 through 75 years and ischemic heart disease (IHD), and to determine the effects of aging on these relationships in a cohort of 3983 Canadian males.

Methods: The Manitoba Follow-up Study is the prospective investigation of cardiovascular disease as it develops in a cohort of 3983 young men. Over a periods of 45 years, from 1948 to 1993, 1094 study members (275) developed clinical evidence of IHD. Blood pressure, body weight, smoking, and presence of diabetes mellitus have been recorded at regular intervals throughout the follow-up period. Using measurements from examinations every 5 years between ages 40 and 75 years, age-specific Cox proportional hazard models were fit to relate these risk factors to IHD.

Results: The adjusted relative risk of IHD for systolic blood pressure, diastolic blood pressure and smoking were found to significantly (p<0.001) decline with advancing age. The adjusted relative risk for body mass index and presence of diabetes mellitus for ischemic heart disease did not very with age (p >0.05). After age 65 years, these risk factors were of little value for the prediction of IHD.

Conclusions: The relative risk and statistical significance of blood pressure and smoking, as risk factors for IDH, decline with age.

Key words: Aging, Ischemic Heart Disease, Longitudinal Studies, Men, Risk Factors.